Influencing Factor Analysis on Initial Poor Graft Function after Liver Transplantation

To analyze the related influencing factors for initial poor graft function (IPGF) after liver transplantation (LT). 107 cases underwent liver transplantation from March in 2014 to November in 2015 were selected randomly. The group of IPGF is confirmed if ALT and/or AST are above 1500IU/L, while non-IPGF below 1500IU/L within 72h after LT. The donor related influencing factors includes age, source, warm ischemic time, cold preservation time, liver biopsy at the end of cold ischemia and if there is a supplementary perfusion at the end of cold ischemia. The recipient related influencing factors includes gender, age, primary liver diseases, Child-Pugh classification, MELD score and ECOG score. The postoperative related influencing factors include intubation time and ICU monitoring time. There are 31 cases (28.97%) in IPGF group and 67 cases (71.03%) in non-IPGF group. The result of ALT and/or AST are significantly higher in IPGF group than those in non-IPGF group (P<0.05). The recovery time of liver function is significantly longer in IPGF group (20.50±5.28d) than that in non-IPGF group (13.20±5.50d) (P<0.01). The donor warm ischemic time is significantly longer in IPGF group (4.34±2.25min) than that in non-IPGF group (2.18±1.90min) (P<0.05). The cold preservation time were significantly longer in IPGF group (9.73±1.19h) than that in non-IPGF group (9.24±0.99h) (P<0.05). There was significant difference between the 2 groups in spite of higher values in Child-Pugh C recipients’ ratio. There were no significant differences between the 2 groups (P>0.05). The rest of related influencing factors had no significant differences between the 2 groups. Longer donor warm ischemic time, cold preservation time and Child-Pugh C recipients’ ration are important risks factors for IPGF. Longer anhepatic time and rewarm ischemic time are the potential risk factors.